H2N2V1, Main, Exploration, bibRecord, 002708

Antigen-dependent proliferation of cloned continuous lines of H-2-restricted influenza virus-specific cytotoxic T lymphocytes.

Identifieur interne : 002708 ( Main/Exploration ); précédent : 002707; suivant : 002709

Antigen-dependent proliferation of cloned continuous lines of H-2-restricted influenza virus-specific cytotoxic T lymphocytes.

Auteurs : M E Andrew ; T J Braciale

Source :

Journal of immunology (Baltimore, Md. : 1950) [ 0022-1767 ] ; 1981.

RBID : pubmed:6167621

Descripteurs français

KwdFr :
- Activation des lymphocytes, Animaux, Antigènes, Antigènes H-2, Clones cellulaires (immunologie), Complexe majeur d'histocompatibilité, Cytotoxicité immunologique, Lymphocytes T (immunologie), Lymphokines (pharmacologie), Souris, Souris de lignée BALB C, Souris de lignée C57BL, Virus de la grippe A (immunologie), Épitopes.
MESH :
- immunologie : Clones cellulaires, Lymphocytes T, Virus de la grippe A.
- pharmacologie : Lymphokines.
- Activation des lymphocytes, Animaux, Antigènes, Antigènes H-2, Complexe majeur d'histocompatibilité, Cytotoxicité immunologique, Souris, Souris de lignée BALB C, Souris de lignée C57BL, Épitopes.

English descriptors

KwdEn :
- Animals, Antigens, Clone Cells (immunology), Cytotoxicity, Immunologic, Epitopes, H-2 Antigens, Influenza A virus (immunology), Lymphocyte Activation, Lymphokines (pharmacology), Major Histocompatibility Complex, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, T-Lymphocytes (immunology).
MESH :
- chemical , pharmacology : Lymphokines.
- chemical : Antigens, Epitopes, H-2 Antigens.
- immunology : Clone Cells, Influenza A virus, T-Lymphocytes.
- Animals, Cytotoxicity, Immunologic, Lymphocyte Activation, Major Histocompatibility Complex, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL.

Abstract

The antigenic requirements for in vitro proliferation of several cloned continuous lines of H-2-restricted influenza virus-specific cytotoxic T lymphocytes (CTL) has been examined. The cloned CTL lines were established from individual splenic CTL precursors obtained from A/JAPAN/305/57 (H2N2)-immune F1 (C57BL/6 X BALB/c) donors. The lines were isolated (by limiting dilution in liquid culture) and expanded in the presence of A/JAPAN/305/57-infected irradiated syngeneic (F1) spleen cells and T cell growth factor (TCGF) of rat spleen origin. Optimal proliferation (and long-term in vitro cultivation) of these H-2-restricted CTL lines required both specific antigenic stimulation in the form of virus-infected syngeneic spleen cells and an exogenous source of TCGF. In addition, the antigenic requirements for proliferation of these lines directly reflected the pattern of H-2-restricted influenza virus-specific recognition at the level of target cell recognition and lysis.

PubMed: 6167621

Affiliations:

Le document en format XML

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<author><name sortKey="Braciale, T J" sort="Braciale, T J" uniqKey="Braciale T" first="T J" last="Braciale">T J Braciale</name>
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<term>Influenza A virus (immunology)</term>
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<term>Cytotoxicité immunologique</term>
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<term>Lymphokines (pharmacologie)</term>
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<front><div type="abstract" xml:lang="en">The antigenic requirements for in vitro proliferation of several cloned continuous lines of H-2-restricted influenza virus-specific cytotoxic T lymphocytes (CTL) has been examined. The cloned CTL lines were established from individual splenic CTL precursors obtained from A/JAPAN/305/57 (H2N2)-immune F1 (C57BL/6 X BALB/c) donors. The lines were isolated (by limiting dilution in liquid culture) and expanded in the presence of A/JAPAN/305/57-infected irradiated syngeneic (F1) spleen cells and T cell growth factor (TCGF) of rat spleen origin. Optimal proliferation (and long-term in vitro cultivation) of these H-2-restricted CTL lines required both specific antigenic stimulation in the form of virus-infected syngeneic spleen cells and an exogenous source of TCGF. In addition, the antigenic requirements for proliferation of these lines directly reflected the pattern of H-2-restricted influenza virus-specific recognition at the level of target cell recognition and lysis.</div>
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Antigen-dependent proliferation of cloned continuous lines of H-2-restricted influenza virus-specific cytotoxic T lymphocytes.

Antigen-dependent proliferation of cloned continuous lines of H-2-restricted influenza virus-specific cytotoxic T lymphocytes.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration H2N2
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